1654Fecal Microbiota Transplant for the Treatment of Recurrent Clostridium difficile Infection via Encapsulated Cryopreserved Concentrated Fecally Derived Bacteria: A Cohort Review
نویسندگان
چکیده
Clostridium difficile Infection via Encapsulated Cryopreserved Concentrated Fecally Derived Bacteria: A Cohort Review Nimit Saraiya, MD; Kaitlin Poeth, MD; Bruce Hirsch, MD; Marcia Epstein, MD; Rebecca Schwartz, PhD; Gerard Honig, PhD; Infectious Diseases, Hofstra North Shore LIJ Health System, Manhasset, NY; Hofstra North Shore LIJ Health System, Manhasset, NY; Symbiotic Health, Inc., New York, NY
منابع مشابه
Clostridium difficile Infection and Fecal Microbiota Transplant.
Clostridium difficile infection (CDI) is a major source of morbidity and mortality for hospitalized patients. Although most patients have a clinical response to existing antimicrobial therapies, recurrent infection develops in up to 30% of patients. Fecal microbiota transplant is a novel approach to this complex problem, with an efficacy rate of nearly 90% in the setting of multiple recurrent C...
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BACKGROUND Fecal microbiota transplantation (FMT) has been shown to be safe and effective in treating refractory or relapsing C. difficile infection (CDI), but its use has been limited by practical barriers. We recently reported a small preliminary feasibility study using orally administered frozen fecal capsules. Following these early results, we now report our clinical experience in a large c...
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Fecal microbiota transplant has become more acceptable as a therapeutic for recurrent Clostridium difficile infection. The FDA has an enforcement discretion policy for practitioner's performing this therapy, which includes informed consent for this experimental treatment. This manuscript describes a typical procedure that can be followed that includes the important aspects of this preparation a...
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BACKGROUND Clostridium difficile infection (CDI), a complication of antibiotic-induced injury to the gut microbiome, is a prevalent and dangerous cause of infectious diarrhea. Antimicrobial therapy for CDI is typically effective for acute symptoms, but up to one third of patients later experience recurrent CDI. Fecal-derived microbiota transplantation (FMT) can ameliorate the underlying dysbios...
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Clostridium difficile infection is increasingly common with a high risk of recurrence despite antibiotic treatment. In cases of recurrent C. difficile infection, fecal microbiota transplant (FMT) is a highly effective treatment option promoting the restoration of normal gut microbiota. Furthermore, preliminary uncontrolled evidence demonstrates possible benefit of FMT in the management of some ...
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